Catalog Number - 70000-PG6

The 70000‑PG6 Diamond Hydride Guard Column Cartridge is a single‑cartridge replacement designed to protect analytical HPLC columns from particulate contamination, strongly retained compounds, and sample‑matrix interferences that can degrade chromatographic performance and shorten column life.

This SKU is intended for laboratories that prefer individual cartridge replacement, including workflows that utilize multiple stationary phases or where guard usage varies by method.

Guard Cartridge Use Case: Preserving the Analytical Separation

Guard cartridges function as a sacrificial stationary phase bed, intercepting contaminants before they reach the analytical column.

Critical Requirement: To maintain chromatographic fidelity, the stationary phase in the guard cartridge must match the analytical column stationary phase.

The Diamond Hydride chemistry used in this cartridge ensures:

• No change in retention mechanism

• No loss of resolution

• No selectivity shift

• No peak distortion or degradation

Using a guard cartridge with mismatched chemistry can erode separation efficiency and compromise analytical results.

Construction & Cartridge Design

Each Diamond Hydride guard cartridge features:

• Stainless steel tube construction for durability and pressure stability

• Stainless steel frits for uniform flow distribution

• Diamond Hydride stationary phase, 4 µm particle size, 100 Å pore size

• Individual labeling for traceability

Each cartridge is shipped in a resealable black Delrin case to prevent drying, contamination, or handling damage prior to installation.

Analytical Column Compatibility

The 70000‑PG6 guard cartridge is designed for use with:

• 3.0 mm ID analytical HPLC columns

• 4.0 mm ID analytical HPLC columns

• 4.6 mm ID analytical HPLC columns

It is intended for Cogent TYPE‑C™ Diamond Hydride analytical columns and HILIC workflows where retention‑mechanism consistency is essential.

A compatible Cogent TYPE‑C™ guard column holder is required and sold separately.

Guard Column Installation Best Practices

To preserve chromatographic efficiency, the guard cartridge should be installed as close to the analytical column inlet as physically possible.

Excess tubing length between the guard holder and analytical column introduces extra‑column (dead) volume, which can result in:

• Band broadening

• Reduced theoretical plates

• Loss of resolution

• Peak tailing or distortion

When installed immediately upstream of the analytical column and paired with matching Diamond Hydride stationary phase, the guard cartridge effectively protects the column without degrading separation performance.

Purpose‑Built for Flexible Replacement & Method‑Specific Use

The 70000‑PG6 single‑cartridge format is commonly selected for:

• Method development laboratories

• Multi‑chemistry analytical environments

• Low‑to‑moderate guard replacement frequency

• Situations requiring precise phase‑to‑method pairing

Proper guard cartridge use can significantly extend analytical column lifetime, reduce downtime, and help maintain long‑term method reproducibility.

System Requirements

• Requires a Cogent TYPE‑C™ guard column holder (sold separately)

• Compatible with standard analytical HPLC systems

• No method changes required when stationary phases are properly matched